Weefsel Pharma- Rifaximin Manufacturer and Exporter in India

Bacteria E. coli, Salmonella, Shigella, Campylobacter, Clostridium, along with viruses like Norwalk agent, Rotaviruses, and parasites like Giardia, Entamoeba, Ascaris, are all capable of intestinal infections. Most of the time such infections manifest in the forms of diarrhea, dysentery, nausea, vomiting, and abdominal pain or even cramping.

As a leading pharmaceutical manufacturer and exporter, Weefsel Pharma has a catalogue of a wide range of medicines for such gastronomical issues. Rifaximin is definitely one name to mention in this regard. 

 

What is Rifaximin? 

With the brand names of Xifaxan (USA) and Zaxine (Canada), Rifaximin is rifamycin-based non-systemic antibiotic; typically used for curing gastrointestinal bacterial infections.

Products :

Product/Composition Strength View
Rifaximin Tablets 200mg, 400mg, 550mg View

How does Rifaximin work?

Rifaximin works by inhibiting RNA synthesis in bacteria by binding to the beta-subunit of bacterial deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase enzyme. This binding blocks the translocation, which eventually stops any transcription. It has broad spectrum antibacterial properties against both gram positive and gram negative anaerobic and aerobic bacteria. As a result of bile acid solubility, its antibacterial action is limited mostly to the small intestine and less so the colon.

 

Ways of administering Rifaximin

Rifaximin is known to be consumed as oral tablets, having either 200 mg or 550 mg strengths; depending upon the severity of the disorder in patients. 

 

Common usage or treatments by Rifaximin

  • Traveler's diarrhea (a stomach and intestinal infection) 
  • Irritable bowel syndrome 
  • C. difficile infection
  • Diverticular disease 
  • Hepatic encephalopathy (liver failure)
  • Mucosal inflammation 
  • Ocular rosacea 
  • Epithelial dysfunction
  • Visceral hypersensitivity

 

Usual side effects of Rifaximin

  • Black or Tarry stools
  • Blood in urine
  • Bloody diarrhoea with stomach cramps
  • Breathing problems 
  • Blurred vision
  • Confusion
  • Dizziness and fainting
  • Drying of mouth and lips
  • Fever
  • Flatulence
  • Headache
  • Muscle and joint pain
  • Nausea and Vomiting
  • Ringing or buzzing in ears
  • Swelling of face, lips, eyes, tongue, hands and feet 
  • Unusual bleeding or bruising
  • Ulcer and sore throat
  • Unusual tiredness and weakness

 

When to avoid Rifaximin?

  • Liver diseases
  • Colitis

 

Compatibility of Rifaximin with other medicines 

  • Live cholera vaccine- Severe
  • Ketoconazole- Medium
  • Pantoprazole- Medium
  • Propranolol- Medium
  • Warfarin- Medium
  • Cyclosporine- Medium

 

Substitutes of Rifaximin

  • 1-naphthol 
  • Acetal 
  • Alcohol 
  • Aromatic heterocyclic compound
  • Aryl alkyl ketone 
  • Aryl ketone 
  • Azacycle 
  • Azole 
  • Benzenoid 
  • Benzimidazole 
  • Benzofuran 
  • Carbonyl group 
  • Carboxamide group 
  • Carboxylic acid derivative 
  • Carboxylic acid ester 
  • Coumaran 
  • Dialkyl ether 
  • Ether 
  • Heteroaromatic compound 
  • Hydrocarbon derivative 
  • Imidazo [1,2-a]pyridine 
  • Imidazole 
  • Ketal 
  • Ketone 
  • Lactam 
  • Macrolactam 
  • Methylpyridine 
  • Monocarboxylic acid or derivatives 
  • N-substituted imidazole 
  • Naphthalene 
  • Naphthofuran 
  • Organic nitrogen compound 
  • Organic oxide 
  • Organic oxygen compound 
  • Organic Heterocyclic compound 
  • Organonitrogen compound 
  • Organo Oxygen compound 
  • Organic Pnictogen compound 
  • Oxacycle 
  • Polyol 
  • Pyridine 
  • Secondary alcohol 
  • Secondary carboxylic acid amide